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Year Number of Results
1975 2
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1978 1
1979 1
1980 1
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1986 2
1987 5
1988 3
1989 9
1990 8
1991 6
1992 14
1993 4
1994 12
1995 6
1996 8
1997 7
1998 13
1999 20
2000 10
2001 11
2002 14
2003 17
2004 20
2005 19
2006 22
2007 25
2008 25
2009 21
2010 27
2011 23
2012 32
2013 35
2014 39
2015 35
2016 32
2017 40
2018 27
2019 50
2020 61
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2022 35
2023 47
2024 19

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785 results

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Page 1
A Structural Perspective of the Role of IP6 in Immature and Mature Retroviral Assembly.
Obr M, Schur FKM, Dick RA. Obr M, et al. Viruses. 2021 Sep 17;13(9):1853. doi: 10.3390/v13091853. Viruses. 2021. PMID: 34578434 Free PMC article. Review.
However, the molecular details underlying this effect have been determined only recently, with the identification of the IP6 binding site in the immature Gag lattice. IP6 also promotes formation of the mature capsid protein (CA) lattice via a second IP6 bindi …
However, the molecular details underlying this effect have been determined only recently, with the identification of the IP6 binding …
Monitoring Intracellular IP6 with a Genetically Encoded Fluorescence Biosensor.
Li X, Wei Q, Zhao K, Wang W, Liu B, Li W, Wang J. Li X, et al. ACS Sens. 2023 Dec 22;8(12):4484-4493. doi: 10.1021/acssensors.3c00268. Epub 2023 Nov 21. ACS Sens. 2023. PMID: 38079595
We also provide proof-of-concept evidence that HIPSer can monitor IP6 levels in real time in HEK293T cells and can be targeted for IP6 detection in the nucleus of HEK293T cells. Moreover, HIPSer could also detect changes in IP6 content induced by chemical inh …
We also provide proof-of-concept evidence that HIPSer can monitor IP6 levels in real time in HEK293T cells and can be targeted for …
IP6: a novel anti-cancer agent.
Shamsuddin AM, Vucenik I, Cole KE. Shamsuddin AM, et al. Life Sci. 1997;61(4):343-54. doi: 10.1016/s0024-3205(97)00092-1. Life Sci. 1997. PMID: 9244360 Review.
A striking anti-cancer action of IP6 has been demonstrated both in vivo and in vitro, which is based on the hypotheses that exogenously administered IP6 may be internalized, dephosphorylated to IP(1-5), and inhibit cell growth. There is additional evidence that Ins …
A striking anti-cancer action of IP6 has been demonstrated both in vivo and in vitro, which is based on the hypotheses that exogenous …
A novel 6-pyrophosphorylating IP6 kinase (IP6-6K) discovered in the protozoon Trichomonas vaginalis.
Wundenberg T, Nalaskowski MM, Löser B, Fanick W, Hackl T, Fürnkranz U, Rehbach C, Lin H, Mayr GW. Wundenberg T, et al. Mol Biochem Parasitol. 2019 Jan;227:53-63. doi: 10.1016/j.molbiopara.2018.12.004. Epub 2018 Dec 26. Mol Biochem Parasitol. 2019. PMID: 30593849
When characterizing the purified protein product of tvip6k1, we discovered that the major activity of the highly active enzyme (2 mumol/min/mg) is a conversion of InsP(6) to 6PP-InsP(5) and not 5PP-InsP(5) as by animal isoforms. Thus TvIP6K1 is a novel IP6-6K. The enzyme a …
When characterizing the purified protein product of tvip6k1, we discovered that the major activity of the highly active enzyme (2 mumol/min/ …
Role of Inositols and Inositol Phosphates in Energy Metabolism.
Chatree S, Thongmaen N, Tantivejkul K, Sitticharoon C, Vucenik I. Chatree S, et al. Molecules. 2020 Nov 1;25(21):5079. doi: 10.3390/molecules25215079. Molecules. 2020. PMID: 33139672 Free PMC article. Review.
Recently, inositols, especially myo-inositol and inositol hexakisphosphate, also known as phytic acid or IP6, with their biological activities received much attention for their role in multiple health beneficial effects. ...
Recently, inositols, especially myo-inositol and inositol hexakisphosphate, also known as phytic acid or IP6, with their biological a …
Metabolism and cellular functions of IP6: a review.
Shamsuddin AM. Shamsuddin AM. Anticancer Res. 1999 Sep-Oct;19(5A):3733-6. Anticancer Res. 1999. PMID: 10625949 Review.
Inositol hexaphosphate (IP6) has a demonstrably effective anti-cancer action against a variety of experimental tumors. ...In rats, the urinary metabolites of IP6 are inositol and IP1. However, in humans 1-3% of total administered IP6 is excreted in the urine …
Inositol hexaphosphate (IP6) has a demonstrably effective anti-cancer action against a variety of experimental tumors. ...In rats, th …
The HIV-1 capsid and reverse transcription.
Aiken C, Rousso I. Aiken C, et al. Retrovirology. 2021 Sep 25;18(1):29. doi: 10.1186/s12977-021-00566-0. Retrovirology. 2021. PMID: 34563203 Free PMC article. Review.
The viral capsid plays a key role in HIV-1 reverse transcription. Recent studies have demonstrated that the small molecule IP6 dramatically enhances reverse transcription in vitro by stabilizing the viral capsid. ...
The viral capsid plays a key role in HIV-1 reverse transcription. Recent studies have demonstrated that the small molecule IP6 dramat …
IP6-stabilised HIV capsids evade cGAS/STING-mediated host immune sensing.
Papa G, Albecka A, Mallery D, Vaysburd M, Renner N, James LC. Papa G, et al. EMBO Rep. 2023 May 4;24(5):e56275. doi: 10.15252/embr.202256275. Epub 2023 Mar 27. EMBO Rep. 2023. PMID: 36970882 Free PMC article.
HIV-1 uses inositol hexakisphosphate (IP6) to build a metastable capsid capable of delivering its genome into the host nucleus. ...Restoring IP6 enrichment with a single mutation rescues the ability of HIV-1 to infect cells without being detected. ...
HIV-1 uses inositol hexakisphosphate (IP6) to build a metastable capsid capable of delivering its genome into the host nucleus. ...Re …
A lysine ring in HIV capsid pores coordinates IP6 to drive mature capsid assembly.
Renner N, Mallery DL, Faysal KMR, Peng W, Jacques DA, Böcking T, James LC. Renner N, et al. PLoS Pathog. 2021 Feb 1;17(2):e1009164. doi: 10.1371/journal.ppat.1009164. eCollection 2021 Feb. PLoS Pathog. 2021. PMID: 33524070 Free PMC article.
We show that whilst IP5, which can functionally replace IP6, engages an arginine ring (R18) at the top of the pore, the lysine ring simultaneously binds a second IP5 molecule. ...Monitoring both the kinetics and morphology of capsids assembled in vitro reveals that while m …
We show that whilst IP5, which can functionally replace IP6, engages an arginine ring (R18) at the top of the pore, the lysine ring s …
785 results